The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
نویسندگان
چکیده
منابع مشابه
Role of regulatory T-cells in autoimmunity.
There has been considerable historical interest in the concept of a specialist T-cell subset which suppresses over-zealous or inappropriate T-cell responses. However, it was not until the discovery that CD4(+)CD25(+) T-cells had suppressive capabilities both in vitro and in vivo that this concept regained credibility and developed into one of the most active research areas in immunology today. ...
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Dendritic cells (DCs) are highly specialized professional antigen-presenting cells that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include clonal deletion, the inhibition of memory T cell responses, T cell anergy, and induction of regulatory T cells (Tregs). These properties have led t...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2019
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2019.06.009